Magaldrate (AS-Gel)
Synthetic Aluminium-Magnesium Hydroxide Sulfate Complex – High-Purity Industrial & Pharmaceutical Grade Antacid Active and Acid-Neutralizing Mineral Intermediate
Magaldrate (AS-Gel) is a synthetic aluminium-magnesium hydroxide sulfate complex used primarily as a controlled-reactivity antacid active and acid-neutralizing mineral intermediate. It is characterized by a layered hydroxide lattice that provides buffered neutralization, consistent ion release, and stable suspension behavior. Industrial buyers procure Magaldrate for pharmaceutical formulations, oral suspensions, nutraceutical blends, and specialty chemical preparations where predictable neutralization kinetics and uniform particle morphology are required.
Natraj Chem supplies Magaldrate sourced from validated high-grade manufacturers and processed under monitored quality systems to ensure compositional accuracy, reproducible performance, and batch-to-batch consistency suitable for regulated and industrial applications.
Chemical Identity
| Parameter | Specification |
|---|---|
| Chemical Name | Aluminium Magnesium Hydroxide Sulfate Hydrate |
| Common Name | Magaldrate, Aluminium Magnesium Hydroxide Complex |
| Molecular Formula | Al₅Mg₁₀(OH)₃₁(SO₄)₂·xH₂O (approximate lattice composition) |
| CAS Number | 86088-01-5 |
| Chemical Class | Layered double hydroxide complex |
| Appearance | White amorphous powder or gel-derived dried mass |
| Solubility | Insoluble in water; reacts with acids |
| pH (10% suspension) | 8.5 – 10.5 |
Technical Properties
Precise physical and chemical characteristics engineered for consistent industrial and pharmaceutical performance.
| Property | Typical Range | Functional Significance |
|---|---|---|
| Aluminium Content | 8 – 12% | Acid neutralization buffering |
| Magnesium Content | 15 – 22% | Rapid acid neutralization phase |
| Sulfate Content | 6 – 12% | Structural stabilization |
| Loss on Drying | ≤ 15% | Moisture stability |
| Particle Size (D50) | 5 – 25 µm | Suspension uniformity |
| Bulk Density | 0.35 – 0.65 g/cm³ | Packaging efficiency |
| Neutralizing Capacity | ≥ 20 mEq HCl/g | Antacid performance metric |
| Heavy Metals | ≤ pharmacopeial limits | Safety compliance |
Values vary by grade and formulation requirement.
Key Functional Benefits
Buffered Neutralization Mechanism
Magnesium hydroxide fraction reacts rapidly while aluminium hydroxide phase provides sustained neutralization, preventing pH rebound throughout the gastric environment.
Layered Lattice Structure
Provides gradual ion exchange and stable dissolution kinetics for consistent, predictable performance across pharmaceutical and industrial formulations.
Low Solubility
Ensures localized reactivity without systemic absorption, making it safe for oral antacid applications with minimal risk of unwanted systemic effects.
Stable Suspension Behavior
Controlled particle morphology prevents rapid sedimentation in liquid oral formulations, ensuring uniform dosing throughout the product shelf life.
Thermal Stability
Maintains lattice structure under standard industrial drying and blending conditions, providing flexibility across diverse manufacturing processes.
Broad Compatibility
Chemically compatible with most excipients, binders, and suspension bases for versatile integration into diverse formulation systems without interference.
Industrial Applications
Select an application sector to explore how Magaldrate serves each industry's specific requirements and performance criteria.
Pharmaceutical Manufacturing
Used as an antacid API or intermediate in oral suspensions, chewable tablets, and combination gastrointestinal formulations. Preferred where controlled acid neutralization rate and minimal systemic absorption are required. Supports IP, BP, and USP formulation standards.
Nutraceutical & OTC Formulations
Applied in digestive support formulations where mineral buffering action is needed alongside herbal or vitamin components. Compatible with natural supplement matrices and OTC product compliance frameworks for domestic and export markets.
Specialty Chemical Processing
Used as a reactive alkaline buffering agent in controlled pH systems and mineral neutralization blends. Provides reliable, predictable buffering performance in process chemistry requiring precise pH management and stable reactivity.
Contract Manufacturing & Formulators
Selected for predictable rheology, suspension stability, and ease of dispersion during mixing operations. Consistent particle characteristics reduce batch variability for contract manufacturers handling multiple product lines simultaneously.
Grades / Specifications Available
Natraj Chem supplies Magaldrate in multiple grades to match your specific application, regulatory requirements, and formulation conditions.
IP/BP Equivalent Grade
Specification-aligned for Indian Pharmacopoeia and BP — suitable for domestic and export pharmaceutical formulations.
Pharma Grade
USP/BP Compliant
Meets pharmacopeial standards with controlled impurities and microbiological parameters. Complete batch documentation provided.
Industrial Neutralization Grade
Optimized for cost-effective bulk applications in chemical processing where pharmacopeial compliance is not required.
Custom PSD Grades
Tailored particle size distributions for suspension stability, rheology control, and OEM formulation compatibility.
Low Heavy Metal Grade
Premium purity with stringent heavy metal screening — ideal for paediatric and sensitive pharma preparations.
💡 Need Help Selecting the Right Grade?
Custom specifications can be sourced based on assay limits, particle size distribution requirements, or formulation compatibility. Our technical team provides expert consultation to identify the optimal grade for your specific application and regulatory framework.
Quality Control Parameters
Every batch moves through a rigorous sequential verification pipeline before being released for supply.
Al & Mg Ratio
Capacity
Content
Drying
Distribution
Analysis
Limits
Only lots meeting all validated acceptance criteria across every parameter are released for supply — no exceptions, no compromise.
Packaging & Supply
Purpose-engineered packaging formats designed for pharmaceutical traceability, moisture protection, and logistics efficiency.
25 kg HDPE Laminated Bags
Multi-layer laminated poly bags with sealed inner PE liner — designed to prevent moisture ingress and maintain product flowability during transit and storage.
Fiber Drums with PE Liner
Sturdy spiral-wound fiber drums fitted with sealed polyethylene liner — preferred format for pharmaceutical-grade Magaldrate requiring enhanced structural protection.
Bulk Jumbo Bags (FIBC)
Heavy-duty flexible intermediate bulk containers with inner liner — optimized for high-volume industrial and chemical processing requirements with forklift-compatible loops.
Custom Pharmaceutical Packaging
Specialized formats with full lot number traceability, batch labelling, and scheduled contract supply programs aligned to GMP documentation requirements.
Supply options include palletized export shipments, lot traceability documentation, and scheduled long-term contract supply programs for uninterrupted manufacturing continuity.
Storage & Handling
Follow these guidelines to preserve neutralization capacity, flow characteristics, and product stability throughout storage and use.
Store in Dry, Ventilated Conditions
Maintain proper environmental controls to preserve product quality and prevent moisture absorption that reduces neutralization capacity over time.
Protect from Moisture Ingress
Keep packaging sealed at all times. Even minor moisture uptake can alter dissolution kinetics, bulk density, and flowability characteristics.
Avoid Contact with Acids
Prevents premature neutralization reactions. Maintain separation from acidic chemicals and acid vapours within the storage environment.
Storage Temperature: Below 35 °C
Avoid prolonged elevated-temperature exposure. Ambient conditions below 35 °C preserve structural integrity, flow characteristics, and neutralizing performance.
Regulatory / Safety Information
Magaldrate is manufactured from controlled mineral sources and conforms to pharmacopeial purity standards — grade dependent.
Safety Data Sheet (SDS)
GHS-aligned hazard communication document covering exposure limits, first-aid procedures, PPE requirements, and safe disposal guidance. Available upon request for workplace safety compliance and regulatory submission.
Technical Data Sheet (TDS)
Detailed chemical and physical specification document for technical evaluation, formulation development, and supplier qualification audits. Grade-specific versions available for each product offering.
Certificate of Analysis (COA)
Batch-specific analytical test results confirming compliance to agreed specification — including assay values, particle size, heavy metals, and microbiological data where applicable for each supplied lot.
Regulatory Compliance Declarations
Full documentation package supporting pharmacopeial compliance, REACH declarations, and industrial regulatory requirements for both export and domestic regulated application environments.
Why Industries Source from Natraj Chem
Four decades of aluminium-based chemical expertise, built on verified supply chains and analytical rigour.
Verified Production Partners
Supplier qualification protocols with documented manufacturer audits ensure consistent source quality across every order.
Consistent Raw Material Provenance
Analytical verification before dispatch eliminates batch-to-batch compositional variability risks from the supply chain.
Specification Reliability
Batch-level quality verification ensures every shipment conforms to agreed acceptance criteria — no exceptions.
Stable Long-Term Supply Chains
Multi-source procurement and inventory coordination support uninterrupted manufacturing continuity for buyers.
Technical Grade Matching
Application-specific grade recommendations matched to your processing conditions and regulatory compliance framework.
Complete Industrial Documentation
COA, TDS, SDS, and regulatory compliance declarations provided alongside every supply — no follow-up required.
Technical Support & Documentation
All technical documents and support services available on request — delivered alongside every supply order.
Certificate of Analysis
Batch-specific quality documentation for regulatory compliance, incoming material verification, and GMP records management.
Technical Data Sheet
Comprehensive specification data supporting formulation development, process integration, and supplier qualification activities.
Method of Analysis
Validated analytical procedures for in-house quality verification and third-party testing protocol alignment.
Regulatory Compliance Documents
Full documentation package for pharmacopeial compliance, REACH declarations, and international regulatory submission support.
Sample Evaluation Support
Pre-qualification samples with full analytical documentation to support formulation trials and procurement approval processes.
Specification Customization
Expert support for tailoring assay limits, particle size distribution, purity parameters, and packaging to your exact OEM or formulation requirements.
Frequently Asked Questions
It is used as an antacid active ingredient providing controlled acid neutralization in oral formulations including suspensions, chewable tablets, and gastrointestinal combination products.
No. It is insoluble in water but reacts with gastric acid, enabling localized buffering without systemic absorption.
Magaldrate is a structured aluminium-magnesium hydroxide complex offering dual-phase neutralization rather than single-component reactivity, providing buffered sustained neutralization with prevention of pH rebound.
Typical values exceed 20 mEq HCl per gram, depending on grade and manufacturing specifications.
Yes. Controlled particle size ensures stable dispersion and minimal sedimentation, making it highly suitable for oral liquid formulations.
Yes, provided pharmaceutical or food-compliant grade is selected to meet applicable regulatory requirements for the intended market.
It is typically supplied as dried powder or processed gel-derived material in HDPE bags, fiber drums, and bulk jumbo bags, with full lot traceability documentation.
A 10% dispersion typically yields pH between 8.5 and 10.5, suitable for antacid applications requiring mild alkaline buffering.
Yes. Verified batches meet pharmacopeial or specified industrial limits for heavy metals, with analytical documentation provided for each batch.
Grade selection depends on application, particle size requirement, purity level, and regulatory compliance needs. Natraj Chem's technical team provides expert guidance to identify the optimal grade for your specific formulation.
Get Technical Data & Custom Quote Today
Magaldrate (AS-Gel) is a technically engineered aluminium-magnesium hydroxide complex designed for predictable neutralization performance, formulation stability, and compositional reliability. Our team provides fast responses with full documentation — no obligation.
- Technical datasheets (TDS) & Safety Data Sheets (SDS)
- Certificate of Analysis (COA) samples
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- OEM / custom manufacturing inquiries